Can Exercise Make You Sick? The Science Explained

Many people feel unwell during or immediately following a demanding workout. This temporary “sickness” can range from acute physical symptoms like nausea, dizziness, or stomach distress, to a delayed susceptibility to infections like a cold or the flu. Understanding the physiological mechanisms behind these reactions helps distinguish between a normal response to exertion and a sign of a serious problem.

Why Intense Exercise Causes Acute Distress

Sickness occurring during or immediately after high-intensity exercise results from the body’s internal resource allocation. Intense muscle work demands a massive increase in oxygenated blood flow. This triggers blood shunting, where the circulatory system redirects blood away from less necessary organs, including the gastrointestinal (GI) tract and the brain.

The reduction in blood flow to the digestive system severely impairs normal GI function during strenuous activity. This lack of circulation means the stomach and intestines cannot properly process contents, leading to common symptoms like nausea, cramping, vomiting, or diarrhea. The brain’s temporary reduction in blood flow also contributes to feelings of lightheadedness, dizziness, or temporary visual disturbances.

Another major contributor to acute distress is the rapid metabolic changes occurring within muscle cells. When exercise intensity exceeds the body’s capacity to produce energy aerobically, it increases its reliance on anaerobic pathways, which leads to a buildup of hydrogen ions (H+). This process causes a temporary state of metabolic acidosis, significantly lowering the pH balance in the body.

This change in cellular chemistry stimulates nerve endings that signal discomfort, contributing to the overall feeling of being unwell and leading to a drop in performance. Prolonged, intense exercise also significantly raises the body’s core temperature, a state known as hyperthermia. If cooling mechanisms cannot keep pace, the resulting heat stress can quickly progress to heat exhaustion, characterized by profound nausea, vomiting, and dizziness.

How Exercise Affects Immune Response

Intense exercise can temporarily affect the body’s ability to fight off viruses and bacteria, potentially leading to infectious illness later on. The relationship between training load and susceptibility to infection is described by the “J-curve” model. This model suggests that while moderate activity lowers the risk of upper respiratory tract infection (URTI), the risk sharply increases with excessive training volume or intensity.

This heightened vulnerability is explained by the “open window” theory, which posits that temporary immune suppression follows a prolonged or exhaustive bout of exercise. For several hours, the concentration and function of certain immune cells, such as lymphocytes and natural killer (NK) cells, show a temporary decrease. The immune system is stressed and temporarily redistributed, which may create a brief window where pathogens can gain a foothold more easily.

Underlying physiological stress, including high levels of stress hormones like cortisol and low energy availability, drives this temporary change in immune function. This condition is associated with athletes who train rigorously without adequate recovery, leading to a state of overreaching or overtraining. Proper recovery, nutrition, and rest are necessary to allow immune function to normalize and prevent delayed illness.

Fueling and Hydration Mistakes That Cause Illness

Many instances of exercise-induced distress that mimic sickness result from mismanaged nutrition and fluid intake rather than the workout intensity. The GI tract operates with reduced blood flow during activity, making it highly sensitive to the consistency and concentration of what is consumed. Consuming fluids too concentrated with carbohydrates can draw water into the intestines, exacerbating GI distress, leading to bloating, cramping, and diarrhea.

Eating high-fat or high-fiber foods immediately before or during exercise significantly slows the rate at which the stomach empties its contents. Since the body prioritizes blood flow to the muscles, these harder-to-digest foods sit longer in the stomach and intestines, leading to reflux, nausea, and abdominal discomfort. This effect is magnified when the body is dehydrated, as the lack of fluid compromises the gut’s ability to absorb nutrients and maintain blood plasma volume.

A lack of sufficient sodium in hydration strategies can also contribute to problems, as sodium is necessary to maintain fluid balance and facilitate the absorption of water and glucose in the gut. To prevent these issues, consume easily digestible, moderate-carbohydrate meals several hours before a workout and utilize a combination of carbohydrates and electrolytes in appropriate concentrations during prolonged activity.

When to Seek Medical Attention

While most exercise-induced sickness symptoms resolve quickly with rest and rehydration, certain signs warrant immediate medical evaluation. Chest pain or discomfort, especially when accompanied by shortness of breath, nausea, or dizziness, should be treated as an emergency and may signal a cardiac issue. Similarly, if dizziness or fainting persists for more than a few minutes after stopping exercise, it requires professional attention.

Symptoms suggesting severe dehydration or serious muscle breakdown require swift action. Signs include dark, tea-colored urine, severe muscle pain, weakness, and persistent vomiting, which can indicate rhabdomyolysis. Any pain that is sudden, sharp, prevents movement, or swelling that does not subside after a few days of rest, should be assessed by a healthcare provider.