Can Caffeine Cause Cancer? What the Science Says

A daily cup of coffee or tea is a deeply ingrained habit for many, sparking curiosity about its long-term health effects, particularly regarding cancer. Scientific research has extensively explored this relationship, providing a clearer picture of how caffeine and coffee consumption might influence cancer risk.

Understanding the Research

Investigating the link between coffee consumption and cancer involves complex scientific studies, such as large-scale epidemiological analyses, cohort studies, and meta-analyses. Researchers track health outcomes in vast populations, observing patterns between dietary habits and disease incidence. Challenges arise from numerous confounding variables, including other dietary choices, lifestyle factors like smoking and physical activity, and genetic predispositions.

Despite these complexities, extensive research indicates that coffee consumption is generally not associated with an increased risk of cancer. Current evidence broadly suggests either a neutral effect or a protective relationship for cancer development.

Specific Cancer Types Examined

Research has explored coffee’s effects on various cancer types. Strong evidence indicates that coffee consumption reduces the risk of liver cancer and endometrial cancer. For instance, increased coffee intake is associated with a decreased risk of endometrial cancer, with some findings suggesting a 29% reduced risk for high consumers compared to low consumers.

For colorectal cancer, numerous studies suggest a protective effect, with some research indicating a 26% lower risk for those drinking one to two cups daily. Men consuming six or more cups of coffee per day have shown a lower risk of prostate cancer, particularly for aggressive forms. While some studies initially showed mixed results for breast cancer, more recent and comprehensive analyses generally find no association between coffee intake and overall breast cancer risk, or even a weak inverse association for postmenopausal women.

Beyond Caffeine Other Factors

Coffee and tea contain a diverse array of bioactive compounds beyond caffeine that contribute to their overall health effects. These include polyphenolic antioxidants like chlorogenic acids, which may prevent oxidative damage, and melanoidins, formed during roasting, that could have prebiotic effects. Diterpenes, such as cafestol and kahweol, are also present and have been studied for both their beneficial anti-carcinogenic properties and their potential to raise cholesterol levels.

The method of preparation can influence the concentration of these compounds. For example, paper filters effectively remove most diterpenes, while unfiltered brewing methods like French press or Turkish coffee allow higher levels to remain. This complex interplay of compounds and preparation methods highlights why the relationship between coffee consumption and cancer risk is nuanced.

Official Health Organization Perspectives

Major health organizations have reviewed extensive research on coffee and cancer, offering clear guidance. The World Health Organization’s International Agency for Research on Cancer (IARC) concluded in 2016 that drinking coffee is “not classifiable as to its carcinogenicity to humans,” indicating insufficient evidence to link it to cancer.

The American Cancer Society (ACS) and the World Cancer Research Fund (WCRF) concur that moderate coffee consumption is generally safe and may reduce the risk of certain cancers, particularly liver and endometrial cancers. These organizations emphasize that coffee’s benefits are often linked to its rich content of antioxidants and other beneficial phytochemicals. They also address concerns about acrylamide, a compound formed during roasting, stating that no links have been established between dietary acrylamide and human cancer risk at typical consumption levels.