Can Antibiotics Make You Fatigued?

Antibiotics are medications specifically designed to treat bacterial infections, combating illnesses ranging from strep throat to more serious conditions. Fatigue, in this context, refers to a profound feeling of tiredness or a significant lack of energy that extends beyond normal sleepiness. While antibiotics are crucial for recovery, many individuals express concern about experiencing fatigue during their treatment course. This article explores the various reasons why antibiotics might contribute to feelings of tiredness and offers guidance on how to manage this common experience.

How Antibiotics Can Cause Fatigue

Antibiotics can lead to fatigue as they clear an infection. A primary mechanism involves disrupting the gut microbiome, the beneficial bacteria in the digestive system. These microbes aid nutrient absorption and energy production; antibiotics can reduce their numbers, affecting how the body processes nutrients. This imbalance may also cause gastrointestinal issues, contributing to tiredness.

The body’s immune system remains active in fighting infection, an energy-intensive process. Even with antibiotics, this ongoing immune response demands considerable energy, contributing to tiredness and a general feeling of being unwell. Additionally, some bacteria killed by antibiotics can release toxins, intensifying fatigue.

Certain antibiotics may also cause drowsiness or malaise as direct side effects. While not common for most, some antibiotics like macrolides (e.g., azithromycin), fluoroquinolones (e.g., ciprofloxacin), cephalexin, and vancomycin have been linked to tiredness or weakness. Metabolizing and eliminating the medication also requires energy, which can contribute to feeling drained.

Is It the Antibiotic or the Infection?

Distinguishing fatigue caused by antibiotics from that caused by the underlying infection can be challenging, as both contribute significantly. Bacterial infections like strep throat, pneumonia, or UTIs often cause substantial fatigue even before treatment. The body expends considerable energy combating the illness.

Healing and recovery demand energy, so fatigue may persist as the body repairs tissues and restores function. This recovery phase is energy-intensive. Fatigue from the infection might be noticeable from the onset of symptoms, whereas antibiotic-induced fatigue might become more apparent after starting the medication.

Other illness-related factors can also worsen fatigue. Poor sleep from symptoms like coughing or pain, dehydration, reduced food intake, or general stress can all contribute to feeling drained. Therefore, feeling tired during antibiotic treatment is often a combination of the body fighting the infection, recovering from it, and potentially experiencing medication effects.

Coping with Fatigue and When to Seek Help

Managing fatigue during antibiotic treatment involves supporting the body’s healing processes. Prioritize adequate rest and sleep, aiming for seven to nine hours nightly to aid recovery. Stay well-hydrated to reduce tiredness, especially if experiencing side effects like diarrhea.

Consume a balanced, nutrient-rich diet to support energy and recovery. Include fruits, vegetables, lean proteins, and whole grains for fuel, and consider probiotic-rich foods like yogurt or kefir for gut health. Avoid strenuous activities and overexertion to conserve energy for healing.

While some fatigue is expected, it is important to contact a healthcare provider if tiredness is severe, worsens, is accompanied by new or concerning symptoms, or does not improve after completing the antibiotic course. This is especially true if fatigue prevents participation in daily activities or affects the ability to drive safely. A doctor can assess the situation, determine the cause, and adjust the treatment plan if necessary.