Can a Uterine Septum Grow Back After Removal?

A uterine septum is a common congenital uterine anomaly, often linked to complications such as recurrent pregnancy loss. This condition is essentially a wall of tissue dividing the interior of the uterus. Following surgical correction, a frequent and understandable question arises: can the uterine septum grow back? Addressing this concern requires understanding the origin of this tissue, the method of its removal, and the factors influencing long-term success after the procedure.

What Defines a Uterine Septum

A uterine septum is classified as a Müllerian duct anomaly, originating during the fetal development of the female reproductive tract. The uterus forms from two separate ducts that fuse together, and the central wall between them is typically reabsorbed to create a single, unified cavity. When this reabsorption process is incomplete, a persistent partition of tissue remains inside the uterus.

The composition of this septal tissue is primarily fibrous or muscular, often lacking the rich blood supply characteristic of the surrounding uterine muscle, known as the myometrium. Septa are categorized based on their extent, ranging from a partial septum involving only the upper cavity, to a complete septum extending to the cervix. Because of its congenital nature, the septum is a structural remnant present from birth and does not regenerate easily.

Surgical Correction of the Septum

The definitive treatment for a uterine septum is hysteroscopic septoplasty, a minimally invasive procedure that is the standard of care. This technique uses a hysteroscope, a thin, lighted telescope inserted through the vagina and cervix into the uterine cavity.

The surgeon visualizes the septum directly on a monitor while the cavity is distended with fluid for clear viewing. Specialized instruments, such as small scissors or an electrosurgical device, are used to divide or resect the septal tissue. The objective is to incise the septum from the top downward until the entire cavity is converted into a single, functional space. This method avoids external incisions and is typically an outpatient procedure.

Assessing the Risk of Recurrence

A uterine septum cannot truly grow back due to its specific origin and composition. Since the septum is a congenital structure composed mostly of avascular, fibrous connective tissue, it lacks the biological capacity to regenerate in the same way that a muscle or the dynamic endometrial lining can. Once the tissue is divided and the uterine cavity is unified, the structure is permanently altered.

The primary concern is not regrowth, but the persistence of a small amount of tissue, known as a residual septum. This occurs when the initial surgical removal is incomplete. The likelihood of a residual septum is influenced by the initial size of the anomaly and the surgeon’s technical skill. The rate of significant residual tissue requiring reoperation is very low after a properly performed hysteroscopic septoplasty. Scientific literature suggests that a small residual septum, defined as less than one centimeter in length, may not negatively affect subsequent reproductive outcomes.

Ensuring Successful Treatment Outcomes

Following hysteroscopic septoplasty, confirming the successful correction of the uterine cavity is crucial. This confirmation is typically achieved one to three months after surgery using specialized imaging techniques. Methods like Saline Infusion Sonography (SIS) or 3D ultrasound provide detailed views of the healed uterine interior. This allows the physician to ensure the septum has been fully removed and the cavity is adequately shaped.

Preventing Intrauterine Adhesions

An important post-operative consideration is the prevention of intrauterine adhesions, which are bands of scar tissue. Temporary measures are sometimes employed to mitigate this risk, including placing a small balloon catheter inside the uterus for a few days or using hormonal therapy. With a successful correction confirmed, patients who undergo septoplasty for reproductive issues experience a significant improvement in their pregnancy and live birth rates.