In vitro fertilization (IVF) involves various medications that stimulate egg production, prepare the uterus, and trigger ovulation. Adhering to specific storage guidelines is crucial for maintaining their effectiveness and safety. Improper storage can reduce potency, potentially affecting treatment outcomes.
IVF Medications Stored in the Refrigerator
Several common IVF medications require refrigeration to maintain their stability and effectiveness. Gonadotropins, such as Gonal-F (follitropin alfa) and Follistim AQ (follitropin beta), used to stimulate follicle growth, need to be stored between 36°F and 46°F (2°C and 8°C) before first use. Menopur (menotropins), another medication for ovarian stimulation, also requires refrigeration before mixing. These medications are sensitive to temperature fluctuations and can degrade if not kept consistently cool.
The “trigger shot” medications, like Ovidrel (choriogonadotropin alfa) and human chorionic gonadotropin (hCG), which help mature eggs and prepare them for retrieval, require refrigeration at similar temperatures. Lupron (leuprolide acetate), used to prevent premature ovulation, needs refrigeration before its initial use, though specific formulations may vary. Medications like Cetrotide (cetrorelix acetate) and Ganirelix (ganirelix acetate), which prevent premature ovulation by suppressing hormones, are also stored in the refrigerator.
IVF Medications Stored at Room Temperature
Not all IVF medications require refrigeration; many are designed to be kept at room temperature. Progesterone, commonly administered as an intramuscular injection (progesterone in oil) or as vaginal suppositories, should be stored at room temperature. Refrigerating these forms of progesterone can cause crystallization or changes in consistency, making administration difficult or affecting absorption.
Oral medications, such as certain birth control pills used to regulate cycles before IVF, also remain stable at room temperature. Antibiotics like Doxycycline, sometimes prescribed during IVF protocols, are also stored at room temperature. For medication storage, “room temperature” refers to a range between 68°F and 77°F (20°C and 25°C). Storing these medications in conditions that are too cold or too warm can compromise their chemical structure and reduce their therapeutic effect.
Essential Tips for IVF Medication Storage
Beyond temperature, protecting medications from environmental factors is important. Direct sunlight, extreme heat, and high humidity can degrade medication compounds. Therefore, storage locations like bathroom cabinets or windowsills should be avoided. A cool, dry place away from light, such as a bedroom dresser drawer or a kitchen cabinet away from the stove, is suitable for room-temperature medications.
Keeping medications in their original packaging is beneficial. The packaging provides protection from light and physical damage, and it clearly displays the medication name, dosage, and expiration date. Always check and adhere to expiration dates, as expired medications may lose potency or even become harmful.
Dispose of any expired or unused medications safely, through pharmacy take-back programs or by following specific guidelines from your clinic. When traveling, especially with refrigerated medications, use an insulated bag with ice packs, ensuring the medication does not directly touch the ice to prevent freezing. Freezing can be as damaging as excessive heat for some medications. Always consult the specific packaging and instructions from your pharmacy or clinic, as formulations and storage recommendations can sometimes differ. If any doubt arises regarding medication storage, or if accidental improper storage occurs, immediately contact your fertility clinic or pharmacist for guidance.