What Is Harpago Used For? A Look at Its Benefits

Harpagophytum procumbens, more commonly known as Devil’s Claw, is a plant that grows in the Kalahari Desert of southern Africa. It gets its name from the small, hook-like projections on its fruit. For generations, the roots of this plant have been used in traditional wellness practices by the indigenous peoples of the area. The plant’s secondary roots are harvested for their constituents and prepared for use in various forms.

Medicinal Uses and Applications

The most common application for Devil’s Claw is managing pain and inflammation associated with joint conditions like osteoarthritis. Studies suggest that taking Devil’s Claw can reduce related pain, particularly in the hip and knee. Its use has allowed some individuals to decrease their reliance on non-steroidal anti-inflammatory drugs (NSAIDs).

Its use extends to addressing generalized low back pain. Research indicates that Devil’s Claw may be effective in reducing lower back pain, with some findings suggesting its effects are comparable to certain NSAIDs.

Beyond joint and back pain, Devil’s Claw has a history of use for other ailments, though these are less supported by modern research. Traditional applications include addressing digestive complaints, fever, menstrual problems, and acting as a bitter tonic to stimulate appetite.

Active Compounds and Mechanism of Action

The therapeutic properties of Devil’s Claw are attributed to a group of active compounds known as iridoid glycosides. Among these compounds, harpagoside has been the primary focus of scientific investigation and is considered a main driver of the plant’s activity.

These iridoid glycosides are understood to have anti-inflammatory properties. The proposed mechanism involves the inhibition of pathways in the body that lead to inflammation. By moderating this response, the compounds can help lessen the swelling and discomfort associated with inflammatory conditions.

The compounds in Devil’s Claw also exhibit analgesic, or pain-relieving, effects. This pain relief is a direct result of the anti-inflammatory action, as reducing inflammation in an area can alleviate pressure and sensitivity. Researchers connect the compound harpagoside directly to this pain-relieving potential.

Dosage and Potential Side Effects

The appropriate dosage of Devil’s Claw often depends on the specific formulation and the concentration of its active compounds. Supplements are typically standardized to a certain percentage of harpagoside, with daily doses ranging from 50 mg to 100 mg of this specific compound. This translates to a wide range in the amount of the total plant extract, from around 600 mg to over 2,600 mg daily. The supplement is available in several forms, including capsules, tablets, powders, and as an ingredient in herbal teas.

Most people who take Devil’s Claw experience no issues, but some may have mild side effects. The most frequently reported adverse effects are digestive in nature, including diarrhea and indigestion. Allergic skin reactions are also a possibility, along with less common side effects like headache or tinnitus.

Certain individuals should exercise caution or avoid using Devil’s Claw. It may interact with various medications and is not recommended for some health conditions. Speaking with a doctor before starting Devil’s Claw is advisable, particularly for people in the following groups:

• Pregnant or breastfeeding women, as it may have uterine-stimulating effects.
• People with gastric or duodenal ulcers, as it can increase stomach acid.
• Individuals with gallstones, because it may increase bile production.
• Those with cardiovascular conditions, as it may affect heart rate and blood pressure.
• People taking blood-thinning medications or drugs to manage diabetes.