Growth Factor 90, or GF-9, is an over-the-counter dietary supplement. It is marketed with claims related to anti-aging and improvements in physical performance, presenting it as a way to naturally support the body’s processes associated with youth and vitality. This has led to consumer questions about what the supplement is and how it functions.
The Science Behind the Claims
The science behind Growth Factor 90 centers on a proprietary blend of specific amino acids: L-Lysine HCl, L-Arginine HCl, Oxo-Proline, N-Acetyl L-Cysteine, and L-Glutamine. These components are intended to function as a “secretagogue,” a substance that signals a gland to increase its secretion of a hormone. In this case, the amino acid blend is designed to target the pituitary gland.
The product’s mechanism involves stimulating the pituitary gland to naturally produce and release more Human Growth Hormone (HGH). By providing these amino acids in a 2.9-gram dose on an empty stomach, the body’s own hormonal output is meant to be enhanced. This approach supports the body’s endocrine system rather than introducing an external hormone, with the goal of achieving elevated HGH levels associated with various physiological benefits.
Distinguishing Supplements from Hormones
An oral supplement like GF-9 differs from prescribed Human Growth Hormone. GF-9 is a mix of amino acids taken to encourage the pituitary gland to release its own HGH. In contrast, prescription HGH is a bio-identical hormone administered through injections, which directly adds the hormone to the body for a more immediate and powerful effect.
The regulatory oversight for these products also differs. GF-9 is regulated by the FDA as a dietary supplement, meaning the manufacturer is responsible for its safety, but the product does not require pre-market approval for effectiveness. Prescription HGH is a controlled substance that has undergone rigorous FDA testing for both safety and efficacy before it can be legally prescribed by a doctor.
The mechanism of action further separates them. An amino acid secretagogue like GF-9 works indirectly by providing signaling molecules to prompt natural hormone production. Prescription HGH bypasses this internal process entirely, delivering a standardized dose of the hormone directly into the user’s system.
Efficacy and Clinical Research
Evidence for Growth Factor 90’s effectiveness is based on a study cited by the manufacturer. This double-blind, placebo-controlled study involved 16 healthy participants. After a single 2.9-gram oral dose of the amino acid blend, researchers measured a 682% mean increase in serum HGH levels after 120 minutes. This figure represents a short-term peak and not a measure of sustained elevation throughout the day.
The practical, long-term benefits of such a transient increase are unclear from this study. The research demonstrated a temporary rise in HGH but did not assess whether this translated to measurable changes in body composition, such as increased muscle mass or decreased body fat. The small sample size also means the results may not be generalizable to a wider population.
A separate, open-label study of individuals with fibromyalgia who took the supplement daily for 24 weeks reported different outcomes. This research showed a sustained increase in Insulin-like Growth Factor-1 (IGF-1), a mediator of HGH’s effects, along with weight loss and symptom improvements. As an open-label study, it lacked a control group, making it difficult to attribute the results solely to the supplement.
Safety and Considerations
The amino acids in Growth Factor 90 are considered safe for healthy adults when taken at recommended doses. The most commonly reported side effects are gastrointestinal, including nausea, bloating, stomach cramps, and diarrhea. In the primary clinical trial for the GF-9 blend, one participant reported adverse events of nausea and lightheadedness.
Certain individuals should exercise caution before using this supplement. People with pre-existing medical conditions, particularly those affecting the kidneys or liver, should consult a healthcare professional. The same advice applies to those with a history of gout, as L-arginine can affect this condition. Pregnant or nursing women are also advised to avoid such supplements.
Amino acid supplements can also interact with certain medications. L-arginine, for instance, may affect blood pressure and blood sugar levels, creating potential interactions with medications for hypertension and diabetes. Anyone considering Growth Factor 90 should discuss it with their doctor to ensure it is appropriate for their health status.