Activated collagen is a preparation of collagen processed to improve how the body can use it. Unlike the large, complex collagen molecule naturally found in connective tissues, activated collagen has been broken down into smaller pieces. This alteration makes it more available for absorption after consumption, and its popularity is part of a growing interest in supplements that support skin, joint, and overall tissue health.
The Process of Collagen Activation
The transformation of collagen into its “activated” state is achieved through a manufacturing process known as hydrolysis. Native collagen is a large, triple-helix protein that is difficult for the body to break down and absorb. Hydrolysis uses water and enzymes to disassemble these large protein structures into much smaller, manageable units.
These smaller units are called collagen peptides or hydrolysates. The hydrolysis process is controlled to break down the collagen without destroying the constituent amino acids. The resulting fine powder dissolves easily in liquids, distinguishing it from gelatin, which is only partially hydrolyzed, and from raw, unprocessed collagen.
The degree of hydrolysis can be adjusted to create peptides of specific sizes. Different enzymes cleave the collagen molecule at precise points, yielding peptides with different molecular weights. This allows manufacturers to create formulations aimed at particular outcomes, as peptide size can influence its biological activity within the body.
Absorption and Bodily Interaction
The small size of collagen peptides allows for efficient absorption from the small intestine into the bloodstream, a quality known as high bioavailability. Compared to large, native collagen molecules which are mostly indigestible, this improved uptake is a primary benefit. Once in circulation, these peptides are transported throughout the body to tissues like skin, bones, and cartilage.
The body does not use these absorbed peptides as direct building blocks for new collagen. Instead, they function primarily as signaling molecules. Specific peptides, like Pro-Hyp and Hyp-Gly, interact with specialized cells called fibroblasts, which are responsible for synthesizing new collagen, elastin, and hyaluronic acid.
When these peptides bind to fibroblast receptors, they act as a feedback signal that stimulates the cells to increase their own natural collagen production. The presence of these peptide fragments in the bloodstream signals that a breakdown of the body’s own collagen has occurred, which triggers a regenerative response. This mechanism is how consuming activated collagen can increase the body’s overall collagen synthesis, promoting tissue repair.
Common Applications and Forms
Activated collagen is available in several forms. The most common is an unflavored powder that can be mixed into beverages like coffee, smoothies, or water. Capsules and tablets offer a pre-measured dose, while liquid collagen shots provide a ready-to-consume option, often combined with vitamins and antioxidants.
The raw materials for these supplements are derived from animal sources. Bovine collagen, from the skin, bones, and muscles of cows, is a prevalent type. Marine collagen, from fish skin and scales, is another popular choice, sometimes favored for its perceived higher absorption rate. Poultry collagen, from chickens, is also used for its benefits related to cartilage and joint health.
When purchasing these products, consumers will find them labeled under a few different names. The terms “hydrolyzed collagen” and “collagen peptides” are scientifically accurate descriptions for what is marketed as “activated collagen.” Looking for these terms on the label ensures the product contains the more bioavailable, processed form of collagen, differentiating it from other protein supplements.