Gui Zhi Fu Ling Wan is a traditional Chinese medicine (TCM) formula, used for over 1,800 years since the late Han Dynasty. This ancient formulation was first documented in Zhang Zhongjing’s “Essential Prescriptions from the Golden Cabinet” (Jingui Yaolue) as a treatment for pregnancy disorders. Its primary purpose in TCM is to invigorate blood circulation and transform blood stasis, which is believed to reduce abdominal masses and alleviate pain. The formula is often recommended by TCM practitioners for various gynecological concerns, including dysmenorrhea (painful menstruation), ovarian cysts, and uterine fibroids, by addressing underlying blood stagnation in the lower abdomen.
Common Side Effects
While generally considered safe, some common and mild side effects can occur. These often involve the digestive system, with reported manifestations such as gastric dysfunction, abdominal pain, nausea, and vomiting. Studies have identified gastric dysfunction, abdominal pain, and nausea as early warning signals.
These gastrointestinal disturbances, including stomach discomfort, often appear within 24 hours. The digestive system is the most frequently affected body system, accounting for a significant portion of reported adverse reactions. Other mild reactions include skin rashes.
Such reactions are generally transient and resolve without significant intervention. The overall incidence of adverse reactions to Gui Zhi Fu Ling Wan is considered low. However, it is always recommended to consult with a qualified TCM practitioner regarding dosage and potential individual responses.
Less Common and Serious Side Effects
Although less frequent, Gui Zhi Fu Ling Wan can lead to more serious side effects that warrant immediate medical attention. Allergic reactions can manifest as skin itch, drug eruption, dermatitis, high fever, or edema. In rare instances, anaphylactic shock has been reported with some traditional Chinese medicines.
Liver enzyme elevation is another potential serious side effect, indicating possible liver damage. Symptoms of liver damage can include anorexia. While Gui Zhi Fu Ling Wan has generally not been found to cause detectable carcinogenic or genotoxic effects in studies, caution is still advised, particularly for individuals with pre-existing liver conditions. Changes in menstrual patterns may also occur. Should any severe symptoms like widespread rash, significant itching, swelling, or signs of liver dysfunction develop, discontinuing the formula and seeking professional medical advice without delay is advised.
Contraindications and Interactions
Gui Zhi Fu Ling Wan should not be used by everyone, as specific conditions and concurrent medications can increase the risk of adverse effects. Pregnancy is a contraindication, as certain Chinese medicines may induce abortion or have unclear safety profiles regarding fetal development. Women who are nursing or in the postpartum period should also exercise caution or avoid using this formula.
Individuals with pre-existing medical conditions, particularly bleeding disorders, should avoid Gui Zhi Fu Ling Wan due to its blood-invigorating properties, which could increase bleeding risk. Similarly, patients with severe liver or kidney dysfunction should not use this formula, as it could exacerbate their conditions. Furthermore, Gui Zhi Fu Ling Wan may interact with conventional medications, especially anticoagulants and antiplatelet drugs. These interactions could increase the risk of bleeding or alter the effectiveness of conventional medications. It is always advisable to inform your healthcare provider about all medications and supplements you are taking to prevent potential complications.