Kanna (Sceletium tortuosum) is a succulent plant from South Africa. For centuries, indigenous communities traditionally chewed it as “kougoed” (‘chewable thing’) to alleviate thirst, combat fatigue, and for social or spiritual purposes. This traditional use highlights Kanna’s role in promoting well-being.
Key Benefits of Kanna
Kanna is recognized for its potential to support emotional well-being and cognitive function. It can uplift mood, reduce stress and tension, and foster a sense of calm. This contributes to a more balanced emotional state and may offer relief from anxiety.
Kanna also supports cognitive performance. Research suggests it can enhance cognitive flexibility, memory, and attention. It may improve focus and mental clarity, aiding during complex cognitive tasks and supporting overall brain function.
How Kanna Works
Kanna’s effects stem from its active compounds, primarily mesembrine alkaloids. These alkaloids interact with the brain through several mechanisms. One primary pathway is serotonin reuptake inhibition (SRI).
By preventing serotonin reabsorption into neurons, Kanna allows this neurotransmitter to remain active longer. Another mechanism involves inhibiting phosphodiesterase 4 (PDE4), an enzyme that degrades cyclic AMP (cAMP). Inhibiting PDE4 increases cAMP levels, which play a role in neuronal functions and synaptic plasticity.
Forms and Dosage
Kanna is available in various forms, including powdered herb, concentrated extracts, tinctures, and capsules. Powdered forms offer versatility for custom dosing. Capsules provide a convenient and precise way to consume Kanna, though their onset of effects might be slower.
Tinctures, which are liquid extracts, are absorbed quickly, especially when taken sublingually. Dosage varies based on the form, concentration, and individual sensitivity. New users are advised to start with a low dose, such as 50 to 100 milligrams per day, and gradually adjust as needed.
Important Considerations and Safety
While Kanna is generally well-tolerated, understanding potential side effects and interactions is important. Some individuals might experience mild side effects, including digestive discomfort, nausea, or headaches. These effects are often mild and temporary, and can sometimes be mitigated by taking Kanna with food or starting with a lower dose.
An important consideration involves Kanna’s interaction with other medications, particularly those affecting serotonin levels. Combining Kanna with selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), or other serotonergic drugs can lead to serotonin syndrome, a serious condition. Individuals taking such medications or those with pre-existing health conditions should consult a healthcare professional before using Kanna.
The legal status of Kanna varies, but it is generally not considered a controlled substance under federal law in the United States. However, state-specific regulations can differ; for instance, Louisiana specifically prohibits Mesembryanthemum species. Despite its generally recognized safety profile, responsible use and professional medical advice are recommended.