Anatomy and Physiology

Subcellular Components and Their Functions

Gain insight into cellular biology by examining the distinct roles and collaborative functions of the components that make up a living cell.

Within every cell exists an organized world of structures known as subcellular components. These components, often called organelles, are analogous to the organs in a body; each is a specialized unit performing a specific job. The coordinated actions of these internal parts allow the cell to grow, reproduce, and carry out its designated role within an organism.

The Nucleus and Ribosomes: Information and Manufacturing

The nucleus serves as the secure vault for the cell’s genetic material, DNA. This organelle is enveloped by a double membrane, the nuclear envelope, which is perforated by nuclear pores. These pores control the passage of molecules like proteins and RNA. By managing access to the DNA, the nucleus directs all cellular activities and ensures the integrity of the genetic blueprint.

Within the nucleus is a dense structure called the nucleolus, where the initial assembly of ribosomes takes place. Ribosomes are the cell’s protein-manufacturing machinery, composed of ribosomal RNA (rRNA) and proteins. They are responsible for translating genetic instructions, carried from the DNA by messenger RNA (mRNA), into the amino acid chains that form proteins.

These protein factories are found in two locations within the cytoplasm. Free ribosomes are suspended in the cytosol and produce proteins that will function within the cell itself. In contrast, other ribosomes are attached to the surface of the endoplasmic reticulum, giving it a rough appearance. These bound ribosomes synthesize proteins destined for insertion into cell membranes or for export from the cell.

Endoplasmic Reticulum and Golgi Apparatus: Processing and Transport

Flowing from the nuclear envelope is the endoplasmic reticulum (ER), an extensive network of flattened sacs and tubules. One region of this network is the rough endoplasmic reticulum (RER), named for the ribosomes studding its outer surface. Proteins synthesized by these attached ribosomes enter the RER’s internal space, or lumen, where they are folded into their correct shapes and undergo initial modifications.

The other region, the smooth endoplasmic reticulum (SER), lacks ribosomes and has a more tubular appearance. The SER is involved in a set of tasks including the synthesis of lipids, such as steroids and phospholipids. It also detoxifies harmful substances and serves as a storage reservoir for calcium ions, which are important signaling molecules.

After processing in the ER, proteins and lipids are transported in small, membrane-bound sacs called vesicles to the Golgi apparatus. Often compared to a post office, the Golgi consists of a series of flattened, stacked pouches called cisternae. Here, molecules are further modified, sorted, and packaged for delivery. As proteins and lipids move through the Golgi stacks, they may have sugar groups added or altered before being dispatched to their final destinations.

Mitochondria, Lysosomes, and Peroxisomes: Energy and Maintenance

Often called the “powerhouses” of the cell, mitochondria generate most of the cell’s supply of adenosine triphosphate (ATP), the primary carrier of chemical energy. This energy conversion occurs through cellular respiration. Mitochondria are distinctive for their two membranes; the inner membrane is extensively folded into structures known as cristae. These folds increase the surface area available for ATP production, and the organelles contain their own DNA and ribosomes.

For cellular cleanup and recycling, cells rely on lysosomes. These small organelles contain digestive enzymes and function as the cell’s waste disposal system. They maintain an acidic internal environment, which activates their enzymes to break down unwanted materials like worn-out organelles or engulfed bacteria. This process also recycles the resulting building blocks for the cell to reuse.

Peroxisomes are small organelles that carry out various metabolic functions, including breaking down fatty acids and detoxifying harmful substances. A function of peroxisomes is to safely manage hydrogen peroxide, a toxic byproduct of metabolism. They contain enzymes like catalase that convert hydrogen peroxide into water and oxygen, preventing it from damaging the cell.

Cytoskeleton and Plasma Membrane: Structure and Interaction

The cytoskeleton is a network of protein fibers extending throughout the cytoplasm that provides structural support and shape to the cell. This internal framework acts as both a skeleton and a muscle system, enabling the cell to maintain its shape and move. The cytoskeleton consists of three main types of filaments: microfilaments, intermediate filaments, and microtubules. These filaments also create a highway system for transporting organelles and vesicles within the cell.

Microfilaments, the thinnest fibers, are made of the protein actin and are involved in muscle contraction and cell movement. Intermediate filaments provide mechanical strength and help anchor organelles in place. Microtubules, the thickest filaments, are hollow tubes that act as tracks for organelle movement and are responsible for separating chromosomes during cell division.

Encasing the cell is the plasma membrane, which acts as a selective barrier between the internal cellular environment and the outside world. This boundary is composed of a phospholipid bilayer with embedded proteins, a structure known as the fluid mosaic model. The plasma membrane regulates the passage of substances, facilitates communication with other cells, and helps cells adhere to one another to form tissues.

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