SR9009, also known as Stenabolic, is a synthetic compound created by the Scripps Research Institute. While often mistaken for a SARM (Selective Androgen Receptor Modulator), it does not interact with androgen receptors and functions through a different biological pathway. Its development was aimed at studying the body’s circadian rhythms. The compound is classified as a research chemical, intended for laboratory investigation only and not for human use.
The Science Behind SR9009
The mechanism of SR9009 centers on its function as a Rev-Erbα agonist. Rev-Erbα is a protein naturally found in the body, with high concentrations in the liver, fat cells, muscle, and brain. This protein is a component of the molecular machinery that governs the circadian rhythm, the body’s internal 24-hour clock that regulates cycles of sleep and wakefulness. It also plays a part in managing lipid and glucose metabolism.
As an agonist, SR9009 binds to and activates Rev-Erbα. This activation enhances the protein’s natural function of repressing the expression of other genes. This action works like a switch to fine-tune metabolic activity and synchronize the body’s internal clock. By activating Rev-Erbα, SR9009 influences metabolic processes and the body’s energy management systems at a cellular level.
This interaction leads to changes in how the body uses and stores energy. For example, activating Rev-Erbα can influence the creation of new mitochondria, the energy-producing centers within cells, and help clear out defective ones. This modulation of circadian and metabolic pathways is the scientific action of SR9009.
Findings from Animal Studies
The significant outcomes associated with SR9009 have been observed exclusively in animal studies, primarily on mice. These preclinical studies reported a range of effects on metabolism, endurance, and health markers. The results are confined to laboratory settings with animal models and have not been confirmed in human trials.
Research in mice showed that activating Rev-Erbα with SR9009 increased metabolic activity. Mice treated with the compound demonstrated a reduction in fat mass and more efficient glucose utilization. The compound also appeared to influence the liver’s handling of lipids and the production of fat-storing cells, with some studies noting lower blood triglycerides and cholesterol.
The most cited finding is the enhancement of physical endurance. Mice administered SR9009 were able to run for longer distances and durations, with some studies reporting a 50% increase in running capacity. Researchers suggested this was due to an increase in the number of mitochondria in skeletal muscle cells. The gene expression in the muscles of treated mice resembled that of a trained athlete.
Risks of Human Consumption
The primary risk associated with SR9009 is the complete lack of human clinical trials. This absence of data means there is no established information on safe dosages, short-term side effects, or long-term health consequences. All available safety data come from animal models, which cannot be directly extrapolated to human physiology.
Because it has not been tested in humans, the full scope of risks is unknown. Theoretical concerns include disrupting the body’s natural circadian rhythm. Altering this biological clock could have downstream implications for sleep patterns, metabolic health, and mental well-being. The effects on major organs after prolonged use also remain unstudied.
The quality and composition of SR9009 sold on the black market present additional dangers. These products are unregulated and may not contain the advertised compound or dosage. SR9009 has very low oral bioavailability, meaning it is poorly absorbed when taken by mouth. Illicit manufacturers may formulate it in unknown solvents to bypass this issue, introducing further risks.
Legal and Competitive Sports Status
SR9009 is not approved for human consumption by the U.S. Food and Drug Administration (FDA) or any equivalent agency. It cannot be legally manufactured or sold as a dietary supplement or medicine. It is, however, sold online under the label “research chemical not for human consumption,” which allows vendors to legally sell it for laboratory purposes.
This “research chemical” classification creates a loophole for individuals to purchase it, but the substance is not intended for personal use. In competitive sports, the World Anti-Doping Agency (WADA) has explicitly banned SR9009. It is listed under Section S4, “Hormone and Metabolic Modulators,” making its use prohibited for athletes both in and out of competition. Athletes testing positive for SR9009 face sanctions.