Rauwolscine, also known by its common name alpha-yohimbine, is a naturally occurring alkaloid. It originates from plants such as the Rauwolfia vomitoria tree, an evergreen found in tropical regions of Africa and Asia. This compound is a popular ingredient in various dietary supplements, particularly those formulated for fitness and weight management.
Promotion of Fat Loss
Rauwolscine is frequently used in dietary supplements to assist with fat loss, targeting stubborn fat areas like the lower back, abdomen, and thighs. It supports lipolysis, the process where stored fat is broken down into fatty acids and glycerol. These fatty acids can then be released into the bloodstream and used by the body for energy.
Its effects are most noticeable when combined with a calorie-restricted diet and regular physical activity. Users report increased fat loss, particularly in stubborn areas.
Stimulant and Nootropic Properties
Beyond its role in fat loss, rauwolscine also acts as a central nervous system stimulant. This stimulant effect can lead to increased energy levels, heightened alertness, and a reduction in perceived fatigue, which is why it is often found in pre-workout supplement formulations.
The compound also exhibits nootropic, or cognitive-enhancing, effects. Users may experience improved focus and concentration. Some users report mood elevation, though its primary impact remains its potent stimulating action.
Biological Mechanism of Action
Rauwolscine exerts its effects by acting as an alpha-2 adrenergic receptor antagonist. Alpha-2 adrenergic receptors are found throughout the body, including on fat cells and nerve terminals, where they inhibit the release of norepinephrine and suppress fat mobilization. By blocking these receptors, rauwolscine effectively removes these “brakes.”
This blockade leads to an increase in norepinephrine levels in the body. Elevated norepinephrine then stimulates other adrenergic receptors, particularly beta-adrenergic receptors, which promotes the breakdown of stored fat. This increase in norepinephrine also contributes to the heightened energy, alertness, and focus observed with rauwolscine use.
Potential Side Effects and Safety
The use of rauwolscine can lead to several potential side effects, primarily due to its stimulant properties. These can include anxiety, jitters, a rapid heart rate, and increased blood pressure. Other reported side effects include excessive sweating, headaches, and occasional gastrointestinal distress.
Individuals with pre-existing cardiovascular conditions, high blood pressure, or anxiety disorders should avoid this supplement due to the risk of exacerbating these conditions. It is important to assess individual tolerance by starting with a very small amount of the supplement. Rauwolscine has been recalled in some regions due to safety concerns.
Dosage and Administration
Dosages of rauwolscine in dietary supplements range from 1 to 3 milligrams (mg) per dose. It is advised to begin with the lowest possible dose, such as 1 mg, to evaluate your body’s reaction and tolerance. This approach helps to minimize the likelihood of adverse effects.
Rauwolscine is recommended to be taken in a fasted state, before morning cardio or exercise. The presence of insulin, released after consuming food, can interfere with its fat-mobilizing effects. Some users also practice cycling the supplement, taking breaks from use for several weeks, to help prevent receptor downregulation.