Is Cerebral Palsy Genetic? The Causes and Risk Factors

Cerebral palsy (CP) is a group of disorders that affect a person’s ability to move and maintain balance and posture. It stems from damage to the developing brain, occurring before, during, or shortly after birth. This damage impacts the brain’s control over muscles. While often associated with birth complications, the question of whether genetics plays a role in CP is an evolving area of scientific understanding.

What is Cerebral Palsy

Cerebral palsy is a non-progressive neurological condition, meaning the brain damage itself does not worsen over time, although the symptoms can change as a child grows. It primarily affects motor skills, balance, and posture, leading to difficulties with movement and coordination. The condition presents as a spectrum, with individuals experiencing varying degrees of impairment. Some individuals with CP may have stiff muscles, known as spasticity, or movements they cannot control.

Symptoms vary widely depending on the extent and location of brain damage. Some individuals can walk independently, while others may require assistive devices like crutches or wheelchairs. CP can also affect other bodily functions, such as swallowing, eye muscle balance, or joint range of motion.

How Genetics Can Play a Role

While cerebral palsy has traditionally been viewed as primarily a result of brain injury during the perinatal period, growing research indicates that genetics can contribute to a significant minority of cases. Studies using DNA sequencing have identified genetic causes in a notable proportion of individuals with CP, with some research suggesting a genetic link in up to 25-30% of cases.

Genetic contributions can involve specific gene mutations or chromosomal abnormalities that affect brain development. For instance, some studies have identified genes like TUBA1A and CTNNB1 as having disruptive mutations linked to CP. While familial cerebral palsy, where the condition runs in families, accounts for a smaller percentage of cases (around 1.6%), genetic predispositions can increase an individual’s susceptibility to developing CP even without a clear family history.

Understanding Other Causes

Beyond genetic factors, the majority of cerebral palsy cases result from brain damage acquired during pregnancy, birth, or early infancy. Damage occurring before birth accounts for approximately 80% of causes. During pregnancy, maternal infections such as rubella, cytomegalovirus, toxoplasmosis, or chickenpox can inflame the developing brain, increasing CP risk. Maternal health conditions like preeclampsia, blood clotting disorders, or untreated hyperthyroidism can also contribute.

Complications during birth, such as a lack of oxygen to the baby’s brain (asphyxia), prolonged labor, or issues with the placenta, are recognized causes. Premature birth, especially before 28 weeks of gestation, and low birth weight (under 3.3 pounds) are also significant risk factors. In early infancy, acquired cerebral palsy, accounting for up to 10% of cases, can result from severe infections like bacterial meningitis or viral encephalitis, head injuries, severe jaundice, or strokes.

Genetic Testing and Family Support

Genetic testing is increasingly considered for individuals with cerebral palsy, particularly when the cause is unclear or if there’s a family history of the condition. This testing typically involves analyzing DNA from blood, saliva, or a cheek swab, often including samples from both parents to determine if a genetic variant was inherited or occurred spontaneously. Whole-exome or whole-genome sequencing are comprehensive tests that can identify mutations in a wide range of genes.

The information gained from genetic testing can provide a definitive diagnosis, offer insights into the prognosis, and help estimate the recurrence risk for future pregnancies. Identifying a genetic cause may also lead to more tailored treatment strategies, such as specific medications or adjustments to physical therapy routines. Genetic counselors play a significant role in this process, helping families understand complex test results, discussing implications for care, and providing support for informed decision-making.

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