Progesterone is a hormone often prescribed for various medical conditions, including those related to reproductive health or hormone replacement therapy. While it can be administered through different routes, rectal administration is sometimes chosen to facilitate systemic absorption of the medication. This method can bypass initial metabolism by the liver, allowing the active compound to enter the bloodstream more directly. Rectal progesterone is commonly used in fertility treatments, particularly when other routes like vaginal administration are not optimal or preferred.
Preparing for Administration
Proper preparation ensures hygiene and effectiveness. Begin by washing your hands thoroughly with soap and water to prevent the introduction of bacteria. Gather all necessary supplies, including the prescribed progesterone medication, which may be in the form of a suppository or a gel with an applicator. If using a suppository, unwrap it carefully. If the suppository feels too soft for insertion, you can briefly hold it under cold water while still in its wrapper or place it in the refrigerator for a few minutes to firm it up. It’s also recommended to have a bowel movement beforehand, if possible, for better absorption and to avoid expelling the medication.
Step-by-Step Administration
Rectal progesterone administration involves specific steps for proper placement and absorption. First, find a comfortable position; lying on your left side with your right knee pulled up towards your chest is often recommended, but sitting or squatting can also work. Relax your buttocks to ease the insertion process. If using a suppository, gently insert the pointed end first into your rectum, pushing it past the anal sphincter. For adults, this typically means inserting it about 1 to 3 inches deep, or far enough so it does not easily come out. If using a gel with an applicator, insert the applicator tip gently into the rectum and depress the plunger to release the medication. After insertion, remove your finger or the applicator.
After Taking Progesterone Rectally
After insertion, remain still to allow for proper absorption. Lying down for about 10 to 15 minutes can help prevent the medication from leaking out as it dissolves. While the medication begins to absorb immediately, serum progesterone levels typically reach their peak approximately two hours after administration. You might experience some mild sensations or an urge to defecate shortly after insertion; however, this feeling usually subsides. Most of the medication is absorbed within three to four hours. If you need to have a bowel movement, it is generally recommended to wait at least an hour after insertion to minimize the risk of expelling the medication.
Key Considerations and When to Seek Advice
Key considerations apply when using rectal progesterone. Common mild side effects can include constipation, flatulence, drowsiness, or headache. Local irritation at the insertion site might also occur, but these are typically not serious. Proper storage of progesterone suppositories is important; while some formulations can be kept at room temperature, many are sensitive to heat and may require refrigeration to prevent melting. If a dose is missed, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule, avoiding doubling doses. Contact your healthcare provider immediately if you experience severe symptoms such as signs of an allergic reaction like hives, difficulty breathing, or swelling of the face, lips, or throat. Additionally, seek medical advice for severe stomach pain, unusual vaginal bleeding, sudden vision changes, or symptoms that might indicate a blood clot, including chest pain, sudden shortness of breath, or leg swelling.