Ketorolac is a medication used for pain management, and breastfeeding parents often have questions about its presence in breastmilk. Understanding its behavior in the body and breastmilk is important for informed decisions regarding infant safety. Knowing factors influencing its transfer and clearance can guide discussions with healthcare providers.
What is Ketorolac?
Ketorolac, commonly known by brand names like Toradol, is a non-steroidal anti-inflammatory drug (NSAID) used for short-term management of moderately severe pain. It works by inhibiting the body’s production of certain substances that cause pain, inflammation, and fever. This medication is typically administered after procedures like surgery to provide relief from acute pain. It is available in various forms, including oral tablets, injections, and nasal sprays.
How Ketorolac Enters Breastmilk
Ketorolac transfers from a mother’s bloodstream into breastmilk, though generally in very small amounts. Factors influencing this include the drug’s molecular weight and its protein binding. Despite high protein binding, which usually restricts transfer, studies show low levels of ketorolac in breastmilk. The estimated infant exposure through breastmilk is minimal, typically ranging from 0.16% to 0.4% of the maternal weight-adjusted dose.
How Long Ketorolac Stays in Breastmilk
The duration ketorolac remains in breastmilk is determined by its elimination half-life, the time it takes for half of the drug to be cleared from the body. The half-life of ketorolac in adults is 5 to 6 hours. This means most of the drug is eliminated from the body after about 25 to 30 hours (approximately five half-lives). In breastmilk studies, ketorolac was not detectable 10 hours after the last dose. Maternal metabolism, dosage, and administration frequency can influence individual clearance times.
Protecting Your Baby While Breastfeeding
When considering ketorolac use while breastfeeding, parents can take steps to protect their baby. While adverse effects are rare with short-term use, it is wise to be informed. Potential effects on infants, though uncommon, could include drowsiness or gastrointestinal issues.
Consult a healthcare provider before taking ketorolac or any medication while breastfeeding. They can assess the situation, discuss alternative pain management, and determine appropriate action. Monitor the infant for any unusual changes in behavior or feeding patterns. Professionals ensure parent’s pain is managed and infant’s well-being prioritized.