Cosentyx (secukinumab) is a medication prescribed for individuals managing certain autoimmune conditions, including plaque psoriasis, psoriatic arthritis, hidradenitis suppurativa, and ankylosing spondylitis. This biologic therapy works by targeting interleukin-17A (IL-17A), a protein that contributes to inflammation in these diseases. Proper storage is essential for maintaining the medication’s effectiveness and safety, ensuring the treatment remains potent and safe for use.
Understanding Cosentyx Out-of-Fridge Stability
Cosentyx prefilled syringes and Sensoready pens can be kept out of refrigeration for up to 4 days. During this time, the medication must be stored at room temperature, not exceeding 30°C (86°F). This allowance is intended for temporary situations, such as travel, where continuous refrigeration might be challenging.
Once Cosentyx has been removed from the refrigerator and reached room temperature, it should ideally be used within this 4-day window. While some product information suggests it may be returned to the refrigerator only one time if it has not been used and has consistently remained below 30°C, the general guidance emphasizes that if the medication has been out for longer than 4 days or at temperatures above 30°C, it must be discarded. This one-time allowance is a specific condition, and the overall principle prioritizes discarding rather than risking compromised efficacy.
Recommended General Storage Practices
For long-term storage, Cosentyx should be kept in a refrigerator at a temperature range of 2°C to 8°C (36°F to 46°F). This consistent cool environment helps preserve the medication’s stability and active properties over its shelf life.
Protecting Cosentyx from light is necessary, so it should remain in its original carton until ready for use. Freezing the medication is not recommended, as extreme cold can damage the protein structure of secukinumab, potentially rendering it ineffective. The medication should also not be shaken, as vigorous movement can lead to degradation of the protein.
Before injecting, allow Cosentyx to warm naturally to room temperature for about 15 to 30 minutes. Avoid using external heat sources, such as hot water or a microwave, to speed up this process, as it can harm the medication’s active ingredient and the device.
Consequences of Storage Deviations
Cosentyx contains secukinumab, a human monoclonal antibody, which is a protein highly sensitive to environmental factors. Improper storage conditions, such as prolonged periods out of refrigeration, extreme heat, direct sunlight, or freezing temperatures, can break down the protein, directly impacting its chemical stability.
A compromised medication may experience a significant loss of potency, failing to deliver the intended therapeutic effect. When the active ingredient is degraded, the treatment may become less effective in reducing inflammation and managing the symptoms of the autoimmune condition. Since Cosentyx does not contain preservatives, improper storage conditions can also increase the risk of microbial contamination. Using a degraded or contaminated product may not only fail to provide desired health benefits but could lead to complications.
What to Do After Improper Storage
If Cosentyx has been stored outside recommended parameters, take immediate action to ensure patient safety. The medication should be discarded if it has been left out of the refrigerator for more than 4 days, or if it has been exposed to temperatures exceeding 30°C (86°F). Similarly, any Cosentyx that has been frozen should be immediately discarded.
Before administering, visually inspect the medication; if it appears discolored, cloudy, or contains any visible particles, it must be discarded. If there is any doubt about the medication’s proper storage or integrity, contact a pharmacist or healthcare provider for advice. This helps ensure only safe and effective medication is administered.