Trazodone is a medication frequently prescribed for insomnia. While primarily an antidepressant, its sedative properties at lower doses make it a common choice for sleep support. Understanding the correct timing for taking Trazodone is important for its effectiveness and your safety.
Optimal Timing for Sleep
For sleep, Trazodone is generally recommended 30 minutes to one hour before bedtime. Some sources suggest a broader window, up to two hours prior. This timing is advised because Trazodone’s sedative effects typically begin within 30 to 60 minutes after ingestion.
The medication reaches peak concentration one to two hours after ingestion. This allows its sleep-inducing effects to align with your intended sleep schedule, helping you fall asleep more readily. While these are general guidelines, individual responses can differ, so it is important to follow your doctor’s specific instructions regarding dosage and timing.
Factors Influencing Trazodone’s Effect
Several factors influence how quickly Trazodone works. Taking it with food, for instance, affects its absorption. When consumed with a meal, peak concentration can extend from about one hour on an empty stomach to approximately two hours.
Eating with the medication can also slightly increase the total amount absorbed, up to 20%. This practice is often suggested to reduce common side effects such as nausea or dizziness. Conversely, taking Trazodone without food can lead to a more rapid, higher peak concentration, which might intensify certain side effects like dizziness and lightheadedness. Individual metabolic rates also mean the onset and duration of effects can vary.
Important Safety Information
When taking Trazodone, be aware of potential side effects and safety considerations. Common side effects include drowsiness, dizziness, tiredness, blurred vision, dry mouth, and lightheadedness, particularly when standing quickly. Due to these effects, avoid activities requiring mental alertness, such as driving or operating machinery, until you understand how the medication affects you.
Never adjust your Trazodone dosage or discontinue the medication without consulting your healthcare provider. Suddenly stopping can lead to withdrawal symptoms like anxiety, irritability, and difficulty sleeping. If you experience concerning or persistent side effects, or if the medication is not working as intended, contact your doctor for guidance. Combining Trazodone with alcohol should be avoided, as both substances can enhance sedative effects, increasing risks such as extreme drowsiness, overdose, slowed breathing, and falls.