How Does a Stroke Begin? The First Signs and Causes

A stroke is a medical emergency where poor blood flow to a part of the brain leads to cell damage and death. This disruption prevents brain tissue from receiving the oxygen and nutrients it needs to function properly. Understanding how a stroke begins, including the initial events and observable signs, can help in recognizing this serious condition promptly.

Understanding Stroke Types

A stroke’s onset can differ based on its type, fundamentally involving either a blockage or a bleed within the brain’s blood supply. An ischemic stroke, the most common type, begins when a blood clot blocks an artery supplying blood to the brain. This blockage can form locally within a brain artery (thrombosis) or it can travel from another part of the body (embolism). Ischemic strokes account for approximately 87% of all stroke cases.

In contrast, a hemorrhagic stroke begins when a brain blood vessel ruptures, causing blood to leak into or around brain tissue. This bleeding can occur within the brain (intracerebral hemorrhage) or in the space between the brain and its surrounding membranes (subarachnoid hemorrhage). The presence of blood then compresses and damages brain cells.

A transient ischemic attack (TIA), often referred to as a “mini-stroke,” starts similarly to an ischemic stroke with a temporary blockage. However, the disruption in blood flow is brief, and symptoms typically resolve within minutes or a few hours. A TIA serves as a significant warning sign that a full stroke may occur soon.

The Brain’s Immediate Response

The moment a stroke begins, whether from a blockage or a bleed, the brain experiences immediate cellular consequences. When blood flow is interrupted, brain cells are deprived of oxygen and glucose, which are their primary energy sources. This lack of essential supplies quickly leads to the failure of cellular processes that maintain brain function, such as ion pumps responsible for cell stability.

Brain cells, particularly neurons, are sensitive to this deprivation and can begin to die within minutes without adequate blood supply. The ensuing cellular damage can involve the accumulation of harmful substances and trigger inflammatory responses. For hemorrhagic strokes, the leaked blood directly irritates and compresses brain tissue, which also impairs its function and can lead to cell death. The specific area of the brain affected by this damage determines the type and severity of neurological deficits experienced.

Recognizing the Warning Signs

Recognizing the sudden onset of stroke symptoms is important for timely intervention. A widely used and easy-to-remember acronym to help identify a stroke is F.A.S.T. This mnemonic guides individuals to look for specific physical and speech changes. Observing any of these signs warrants immediate medical attention.

“F” is for Face drooping: One side of a person’s face may suddenly droop or feel numb, becoming noticeably uneven when they try to smile.
“A” is for Arm weakness: When asked to raise both arms, one arm may drift downward or be unable to be lifted fully due to sudden weakness or numbness.
“S” is for Speech difficulty: The person’s speech might become slurred, garbled, or they may have trouble speaking clearly or understanding what others are saying.
“T” is for Time to call emergency services: If any of these signs are observed, even if they seem to improve, call 911 immediately. Acting quickly can help improve outcomes.

Other sudden symptoms can include:
Numbness or weakness in a leg.
Sudden vision changes.
Dizziness.
Loss of balance.
A severe headache, particularly with hemorrhagic strokes.

Factors Contributing to Stroke Onset

Several underlying health conditions and lifestyle choices can increase the likelihood of a stroke beginning. High blood pressure stands as a leading factor, as it can damage blood vessels throughout the body, including those supplying the brain. Over time, uncontrolled high blood pressure can cause arteries to narrow, stiffen, or become more prone to bursting.

High cholesterol contributes to the buildup of fatty deposits, known as atherosclerosis, within arteries. These deposits can narrow blood vessels and lead to the formation of blood clots that can then block blood flow to the brain. Diabetes also significantly increases stroke risk, as consistently high blood sugar levels damage blood vessels, making them more susceptible to blockages. Individuals with diabetes face about 1.5 to 2 times higher risk of stroke compared to those without the condition.

An irregular heartbeat, such as atrial fibrillation, can cause blood clots to form in the heart, which may then travel to the brain and initiate an ischemic stroke. Lifestyle factors like smoking, obesity, physical inactivity, and a poor diet can also contribute to these conditions, further increasing the potential for a stroke to begin.