Probiotics are beneficial microorganisms that support human health, particularly within the digestive system. Among probiotics, Lactobacillus reuteri is a well-recognized species. Lactobacillus reuteri 6475 is a specific, well-researched strain known for its distinct properties and potential health applications.
What is Lactobacillus reuteri 6475?
Lactobacillus reuteri 6475, also known by its scientific designation ATCC PTA 6475, is a specific and patented strain. It was originally isolated in 1997 from the breast milk of a Finnish woman. Its unique genetic makeup distinguishes it from other Lactobacillus reuteri strains and other probiotics. This strain has demonstrated strong adherence to intestinal mucus and exhibits greater acid tolerance in simulated stomach conditions compared to L. reuteri DSM 17938. These characteristics contribute to its ability to survive the harsh environment of the gastrointestinal tract and temporarily colonize various parts of the digestive system.
Specific Health Applications
Lactobacillus reuteri 6475 has shown promise in several areas of health. Research indicates its potential role in supporting gut health, influencing the immune system, and contributing to other systemic benefits. The strain has been investigated for its impact on digestive comfort, including a reduction in abdominal pain in children and an increase in bowel movement frequency in cases of constipation. L. reuteri 6475 has also been linked to immune system modulation, demonstrating an ability to reduce inflammation.
Animal studies have explored the effects of L. reuteri 6475 on bone health, showing a potential to increase bone mineral density in mice. While human trials on early postmenopausal women have not consistently shown a significant impact, a study in older women (75-80 years old) with low bone mineral density indicated that L. reuteri 6475 reduced bone loss by approximately half over 12 months. Animal research also suggests that L. reuteri 6475 may improve skin quality and contribute to thicker, more lustrous hair.
How Lactobacillus reuteri 6475 Works
The beneficial effects of Lactobacillus reuteri 6475 stem from several biological mechanisms. One primary way it functions is by producing antimicrobial compounds. It synthesizes reuterin, a broad-spectrum antimicrobial substance that can inhibit the growth of various harmful bacteria, fungi, and protozoa. This action helps maintain a balanced microbiota in the gut by suppressing the overgrowth of potential pathogens.
Lactobacillus reuteri 6475 also interacts with the gut lining to strengthen the intestinal barrier. It promotes the production of mucus, forming a protective layer over the epithelial cells that line the gastrointestinal tract. This mucus layer acts as a barrier, preventing the adhesion and invasion of pathogens. The strain can also increase the expression of tight junction proteins, which are responsible for strengthening the connections between intestinal cells and preventing unwanted substances from entering the bloodstream.
The strain’s influence extends to the immune system. L. reuteri 6475 can modulate the activity of immune cells within the gut-associated lymphoid tissue. It has been shown to suppress the production of pro-inflammatory cytokines while promoting the development and function of regulatory T cells, which help to control inflammation throughout the body. Additionally, L. reuteri 6475 can produce histamine, which has been shown to suppress tumor necrosis factor (TNF) production, contributing to its anti-inflammatory properties.
Incorporating Lactobacillus reuteri 6475 into Your Routine
For those considering incorporating Lactobacillus reuteri 6475, it is typically available in specific probiotic supplements. These supplements often contain freeze-dried viable bacteria, with the number of live bacteria guaranteed until expiration. L. reuteri 6475 is sometimes combined with other L. reuteri strains, such as DSM 17938, in certain products.
Dosage recommendations for L. reuteri strains generally range from 1 billion to 100 billion colony-forming units (CFU) taken daily. For L. reuteri 6475 specifically, doses up to 1 x 10^11 CFU per day have been well-tolerated in human studies for periods up to 28 days. While L. reuteri can survive passage through the gastrointestinal tract, its colonization is transient, meaning it is typically washed away within one to two weeks. Therefore, regular daily intake is often suggested to maintain adequate levels in the gut. It is advisable to consult with a healthcare professional before starting any new supplement, including probiotics, to determine the appropriate dosage and ensure it aligns with individual health needs.