Does Nystatin Cause Diarrhea? What You Should Know

Nystatin is a medication commonly prescribed to treat various fungal infections throughout the body. It works by targeting specific components of fungal cells, helping to eliminate the infection. This medication is effective in managing fungal infections and alleviating symptoms caused by these microorganisms.

Understanding Nystatin

Nystatin is classified as a polyene antifungal medication. It functions by binding to ergosterol, a substance present in the cell membranes of fungi. This action disrupts the fungal cell’s structure, increasing its permeability and leading to the leakage of internal components, ultimately causing the fungus to die. Nystatin shows activity against a wide range of yeasts and yeast-like fungi, particularly Candida species.

This medication is primarily used to treat fungal infections of the skin, mouth, and digestive tract. For example, oral nystatin is commonly prescribed for oral thrush and fungal infections within the gastrointestinal tract. Nystatin is available in various forms, including oral suspensions, tablets, and topical creams or ointments, depending on the infection’s location.

Nystatin and Diarrhea: The Connection

Diarrhea is a recognized side effect associated with oral nystatin use. It is a common gastrointestinal upset. Although it can be bothersome, the diarrhea experienced is often mild and tends to resolve on its own.

The occurrence of diarrhea with nystatin is likely due to its localized action within the digestive system. Since nystatin is not significantly absorbed into the bloodstream, most of the orally administered medication passes through the digestive tract unchanged. This local presence can lead to irritation of the gastrointestinal lining or alterations in the gut environment. Inactive ingredients, such as sucrose in oral suspensions, might also contribute to gastrointestinal disturbances in some individuals.

Managing Diarrhea While Taking Nystatin

Individuals who experience mild diarrhea while taking nystatin can take several steps to manage their symptoms effectively. Staying well-hydrated is important, by drinking plenty of fluids like water or clear broths. Consuming bland foods can also help to alleviate gastrointestinal discomfort. Taking oral nystatin with food may help reduce stomach-related side effects.

It is important to seek medical attention if diarrhea becomes severe, persistent, or is accompanied by other concerning symptoms. Signs that warrant immediate medical evaluation include signs of dehydration, fever, or the presence of blood in the stool. A healthcare provider should always be consulted before stopping the medication or making any significant changes to the treatment plan.

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