Lisinopril alone does not cause frequent urination. However, if it’s part of a combination medication with a diuretic, increased urine output can occur. Rarely, serious underlying issues related to lisinopril may also change urination patterns.
Lisinopril and Urination Changes
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, works by relaxing blood vessels to lower blood pressure. It is not inherently a diuretic, so it does not directly increase urine production. This medication primarily influences the renin-angiotensin-aldosterone system, which helps regulate blood pressure and fluid balance without directly promoting diuresis.
Many people, however, take lisinopril in a combination pill that also contains a diuretic, such as hydrochlorothiazide. These combination medications are designed to enhance blood pressure control by both relaxing blood vessels and increasing the removal of excess fluid from the body through urine. If you are taking such a combination medication, an increase in urine output is an expected effect, and this can lead to more frequent trips to the bathroom, especially at night. To help mitigate nighttime awakenings, healthcare providers often recommend taking these combination medications at least four hours before bedtime.
Lisinopril can indirectly influence the body’s fluid balance, and maintaining proper hydration is advised to support its effects. A rare but serious connection exists between lisinopril and kidney damage, which can manifest as a change in urination frequency. This could involve urinating more often or, conversely, significantly less often.
When to Consult a Healthcare Provider
A significant decrease in urination after starting lisinopril requires prompt attention from your healthcare provider. This change could indicate a serious kidney issue, as lisinopril can, in rare cases, affect kidney function. Timely assessment is important to determine the cause and guide appropriate management.
Other serious but rare side effects of lisinopril also require prompt medical consultation. These include:
- Fainting spells, which could signal a significant drop in blood pressure.
- Muscle cramps.
- Signs of an infection, such as fever or sore throat.
- Noticeable changes in heart rate, like a very slow or irregular pulse.
- Signs of liver problems, such as yellowing of the skin or eyes, dark urine, or persistent nausea.
Always discuss any new or worsening symptoms with your healthcare provider to ensure your well-being and medication effectiveness.