Lexapro (escitalopram) is a medication primarily prescribed to manage major depressive disorder and generalized anxiety disorder. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Heartburn and Lexapro: A Common Occurrence
Heartburn or acid reflux symptoms are a recognized occurrence when taking Lexapro. Gastrointestinal issues, including indigestion and nausea, are frequently reported side effects during the initial phase of treatment. Heartburn is a common adverse reaction associated with escitalopram use. Studies indicate that nausea, a related gastrointestinal symptom, was experienced by nearly 20% of individuals in clinical anxiety studies, confirming these complaints are a common part of adjusting to Lexapro.
Why Heartburn Happens and If It Resolves
Lexapro influences heartburn by increasing serotonin levels in the brain. Serotonin receptors are also present throughout the digestive system, and altering their levels can affect gut function, including motility and secretion. This may lead to changes in gastric acid secretion or a reduction in protective mucus production in the gastrointestinal tract.
Another factor is that Lexapro, like other antidepressants, may relax the lower esophageal sphincter. This muscular valve prevents stomach acid from flowing back into the esophagus. If it relaxes, stomach acid can reflux upward, causing the burning sensation.
For many individuals, side effects like heartburn often lessen or resolve as the body adjusts to the medication. This adjustment period typically occurs within the first two to six weeks of starting treatment. However, some side effects may persist. If heartburn remains bothersome or worsens beyond this timeframe, it warrants further attention.
Strategies for Relief and When to Consult a Doctor
Practical adjustments can help manage heartburn from Lexapro. Taking the medication with food can prevent stomach upset and reduce nausea. Eating smaller, more frequent meals instead of large ones can also be beneficial. Avoiding foods and drinks known to trigger heartburn, such as spicy, fried, or fatty items, can further alleviate symptoms.
Lifestyle modifications also provide relief. Avoid lying down immediately after eating, allowing at least two to three hours for digestion. Elevating the head of the bed by about six inches can use gravity to help keep stomach acid down, especially if heartburn is worse when lying flat. Over-the-counter remedies like antacids, H2 blockers, or proton pump inhibitors (PPIs) can reduce stomach acid and relieve symptoms. However, consult a healthcare provider before long-term use of these medications, as some, like famotidine, can interact with escitalopram and affect heart rhythm.
Consult a healthcare provider if heartburn is severe, persistent, or worsens. Seek medical attention if heartburn is accompanied by other concerning symptoms, such as difficulty swallowing, chest pain unrelated to heartburn, or unexplained weight loss. If over-the-counter remedies are ineffective or you experience any other new or unusual symptoms, seek medical advice. Do not stop taking Lexapro suddenly without medical guidance, as this can lead to withdrawal symptoms or a worsening of the underlying condition.