All medications, including custom-prepared ones, have specific shelf-life guidelines. For compounded semaglutide, used for blood sugar management and weight loss, understanding its stability and longevity is crucial due to its unique preparation. Proper handling and storage maintain its therapeutic benefits.
What is Compounded Semaglutide
Compounded semaglutide is prepared by a licensed compounding pharmacy to meet individual patient needs. This customization can involve adjusting dosages, creating allergen-free formulations, or offering different delivery methods. Pharmacists mix ingredients to create a tailored product.
It differs from commercially manufactured, FDA-approved semaglutide products like Ozempic or Wegovy. Compounded versions do not undergo the same FDA approval processes for safety and stability. Their quality and effectiveness can vary depending on the specific pharmacy and its practices.
Factors Affecting Its Stability
Compounded medications are assigned a “Beyond-Use Date” (BUD) by the compounding pharmacist, rather than an expiration date. This BUD indicates the date after which the medication should not be used, determined by drug stability data, the specific formulation, and recommended storage conditions. The BUD for compounded semaglutide typically ranges from 30 to 90 days when stored correctly.
Environmental factors significantly influence the stability of compounded semaglutide. Exposure to direct sunlight or bright light can cause the active ingredient to degrade. Temperature fluctuations, particularly high heat or freezing temperatures, also negatively impact the medication’s integrity. The specific excipients, solvents, and concentration used in the compounding process also play a role in its overall stability.
The type of container and exposure to air can also affect compounded semaglutide. Opening and closing the vial allows air and moisture to enter, which can promote microbial growth. The vial or syringe material, and its protection from light and air, contributes to maintaining its integrity over time.
Consequences of Using Expired Doses
Using compounded semaglutide past its Beyond-Use Date impacts treatment effectiveness and safety. A primary concern is reduced efficacy, as the active ingredient can degrade over time. This degradation leads to a loss of potency, rendering the medication less effective at managing blood sugar or supporting weight management goals.
As semaglutide breaks down, it may form new chemical compounds. These degradation products could be inactive or, in rare instances, potentially harmful. Injectable medications also carry an increased risk of bacterial contamination as they age, which can lead to infections.
Proper Storage and Handling
To ensure the longevity and safety of compounded semaglutide, adhere to the Beyond-Use Date provided by the compounding pharmacy. This date indicates the period during which the medication is expected to remain stable and effective. Most compounded semaglutide formulations require refrigeration, typically at temperatures between 2°C and 8°C (36°F and 46°F). Avoid freezing the medication, as this can damage its molecular structure and reduce its effectiveness.
Protecting the medication from light is also important for maintaining its potency. Store compounded semaglutide in its original, light-protective packaging or in a dark place to prevent degradation. Patients should avoid leaving the medication in areas prone to significant temperature fluctuations, such as in a hot car or near a window, as extreme temperatures can compromise its stability. Always consult the compounding pharmacist for specific storage instructions.