Do Antihistamines Really Prolong a Cold?

The common cold is a frequent ailment, often accompanied by a range of uncomfortable symptoms. When experiencing a cold, many individuals consider using antihistamines to find relief. A common question arises regarding these medications: do antihistamines inadvertently prolong the duration of a cold? This article explores how antihistamines interact with cold symptoms and addresses the concern about their effect on the illness’s length.

How Antihistamines Affect Cold Symptoms

Antihistamines primarily work by blocking histamine H1 receptors in the body. Histamine is a chemical involved in allergic reactions, and its release contributes to symptoms such as sneezing, a runny nose, and itchy or watery eyes. By blocking these receptors, antihistamines can help alleviate some of these specific symptoms.

First-generation antihistamines, like diphenhydramine, can cross the blood-brain barrier, leading to side effects such as drowsiness and dry mouth. They also have effects on other receptors, which contributes to their drying properties and may help with a runny nose. Second-generation antihistamines, such as loratadine, are less likely to cross the blood-brain barrier, resulting in fewer sedating effects. Research indicates that second-generation antihistamines are not effective for cold symptoms, and first-generation antihistamines offer only limited short-term benefits.

Do Antihistamines Prolong a Cold?

Antihistamines do not prolong the actual viral infection that causes a common cold. The duration of a cold, typically lasting 7 to 10 days, is determined by the body’s immune response fighting off the virus. Antihistamines do not suppress the immune system in a way that would extend the course of a viral illness.

The perception of a prolonged cold when using antihistamines can arise from their effects on mucus. First-generation antihistamines, known for their drying properties, can thicken nasal secretions. This thickened mucus may become harder to clear from the nasal passages and throat, potentially leading to a feeling of persistent congestion or a lingering cold. By alleviating some symptoms, antihistamines might also mask the natural progression of the cold, making it seem as though the illness is not resolving. While clearing mucus can provide comfort, it does not shorten the cold’s duration.

Effective Strategies for Cold Relief

While there is no cure for the common cold, several strategies can help manage symptoms and promote recovery. Staying hydrated by drinking plenty of fluids like water, clear broths, and herbal teas is helpful for thinning mucus and preventing dehydration. Rest also supports the body’s immune system as it fights the infection.

Other strategies for cold relief include:

  • Using a clean humidifier or cool-mist vaporizer to add moisture to the air, soothing irritated nasal passages and loosening congestion.
  • Saline nasal sprays or rinses for moisturizing nasal passages and thinning mucus.
  • Over-the-counter decongestants to reduce nasal congestion.
  • Pain relievers, such as acetaminophen or ibuprofen, to alleviate aches and fever.
  • Gargling with salt water for temporary sore throat relief.
  • Honey to soothe a cough for individuals over one year of age.