Xifaxan (rifaximin) is a medication prescribed for digestive conditions like traveler’s diarrhea and irritable bowel syndrome with diarrhea (IBS-D). Patients sometimes consider crushing tablets due to difficulty swallowing. Understanding the proper way to take medication is important for its safety and effectiveness.
Understanding Xifaxan’s Formulation
Xifaxan is typically manufactured as a film-coated tablet, available in strengths such as 200 mg and 550 mg. This coating is crucial for how the drug functions within the body.
The film coating ensures rifaximin reaches its intended target: the gastrointestinal tract. Very little is absorbed into the bloodstream, typically less than 0.4%. This localized action addresses gut issues without significant systemic exposure. The manufacturer has not explicitly stated whether Xifaxan tablets can be crushed, split, or chewed in their official prescribing information.
Why Crushing Might Be Problematic
Crushing Xifaxan tablets can compromise their intended function. Disrupting the film coating alters how the drug is released within the digestive system. This might lead to faster dissolution in the stomach, which could reduce its effectiveness in the lower gut where its action is primarily desired.
Altering the tablet’s form could also impact its absorption. While rifaximin is known for minimal systemic absorption, crushing could theoretically increase the amount absorbed into the bloodstream. Additionally, removing the protective coating might result in an unpleasant taste. Inaccurate dosing is also possible if the entire crushed amount is not consumed.
Alternatives for Swallowing Difficulties
Individuals experiencing difficulty swallowing Xifaxan tablets should first consult a healthcare professional, such as their doctor or pharmacist, before attempting to alter the medication. These professionals can offer personalized guidance.
Several techniques can help with swallowing tablets. The “pop-bottle” method involves placing a tablet on the tongue and swallowing with water from a narrow-necked bottle using a sucking motion. Another strategy is placing the tablet on the tongue, taking a sip of water, and tilting the head slightly forward before swallowing. Some find it helpful to place the tablet on soft food, like applesauce or yogurt. While Xifaxan is not typically available in liquid form, discussing with a healthcare provider if other crushable medications for the same condition exist, or if lubricating gels or sprays might be appropriate, can provide practical solutions.