Trelegy Ellipta is a medication commonly prescribed for individuals managing chronic obstructive pulmonary disease (COPD) and asthma. This article explores the relationship between Trelegy and body weight, specifically addressing concerns about weight gain and other contributing factors.
What is Trelegy
Trelegy Ellipta is an inhalation powder that combines three different medications into a single inhaler: fluticasone furoate, umeclidinium, and vilanterol. It is approved for the daily maintenance treatment of COPD and asthma in adults.
The three components work together to improve breathing and manage respiratory symptoms. Fluticasone furoate is an inhaled corticosteroid (ICS) that helps reduce inflammation in the lungs. Umeclidinium is a long-acting muscarinic antagonist (LAMA), which acts as a bronchodilator to relax and open the airways. Vilanterol is a long-acting beta2-agonist (LABA), another type of bronchodilator that also helps relax the muscles around the airways, making breathing easier.
Does Trelegy Directly Cause Weight Gain
Weight gain is not a commonly reported direct side effect of Trelegy Ellipta in clinical trials. Studies did not identify weight gain as a significant adverse event. While one of Trelegy’s components, fluticasone, is an inhaled corticosteroid, its systemic absorption is generally lower compared to oral corticosteroids.
Oral corticosteroids, such as prednisone, are known to cause weight gain, especially with long-term use, due to their higher systemic effects. Inhaled corticosteroids are designed to act primarily in the lungs, minimizing widespread effects throughout the body. Although some systemic absorption of inhaled corticosteroids does occur, it is typically not sufficient to cause the same degree of weight gain as oral steroid medications. Therefore, significant weight gain is not considered a typical direct consequence of taking Trelegy.
Other Factors Influencing Weight
Even though Trelegy itself is not typically a direct cause of weight gain, several other factors can influence an individual’s weight while taking the medication. Improved lung function and reduced respiratory symptoms from Trelegy might indirectly lead to weight changes. When breathing becomes easier, individuals may experience increased activity levels and potentially an improved appetite. This increased intake, if not balanced with physical activity, could result in weight gain.
Many individuals with COPD or asthma also manage other health conditions that can affect weight, such as obesity, cardiovascular disease, or metabolic syndrome. Certain other medications prescribed for these co-occurring conditions can also contribute to weight gain. Additionally, lifestyle changes, such as quitting smoking, can sometimes be associated with initial weight gain.
Strategies for Weight Management
Managing weight effectively involves adopting a balanced approach to lifestyle choices, especially for individuals with respiratory conditions. Focusing on nutrition includes consuming five to six small, frequent meals throughout the day instead of two or three large ones. Incorporating whole grains, fruits, lean proteins, and healthy fats can provide necessary nutrients and energy.
Regular physical activity, tailored to individual capacity and in consultation with a healthcare provider, plays an important role in weight management and overall lung health. Maintaining adequate hydration and managing stress are also components of a healthy lifestyle that support weight management.
When to Talk to Your Doctor
It is important to communicate any significant or unexplained changes in weight to your healthcare provider. This is particularly true if weight gain is accompanied by new or worsening symptoms. Your doctor can help determine the underlying cause of any weight changes, whether it relates to medication, other health conditions, or lifestyle factors.
Reporting unintentional weight loss exceeding 5% of your body weight over 6 to 12 months also warrants medical attention. Never discontinue Trelegy or any other prescribed medication without first consulting a healthcare professional. Your doctor can provide guidance and adjust your treatment plan as needed, ensuring your respiratory health and overall well-being are managed appropriately.