Nexplanon is a long-acting reversible contraceptive that prevents pregnancy for up to three years by continuously releasing the progestin hormone etonogestrel from a small rod inserted under the upper arm’s skin. Many users inquire about potential side effects, including tiredness or fatigue. This article explores the connection between Nexplanon and fatigue, examining its mechanisms and other contributing factors.
How Nexplanon Might Influence Tiredness
Nexplanon’s primary mechanism involves the continuous release of etonogestrel, a synthetic progestin, which works to prevent ovulation and thicken cervical mucus. Hormones, including progestins, can influence various bodily functions, including energy regulation and sleep patterns. The consistent presence of etonogestrel in the system might, for some individuals, subtly affect the central nervous system or neurotransmitter activity, potentially leading to sensations of reduced energy or fatigue.
Individual responses to hormonal birth control methods vary due to physiological differences. While some users report an energy dip or increased tiredness, others may not perceive any change. This potential side effect is generally mild and often subsides as the body adjusts to the new hormonal balance over the first few months. If tiredness persists or becomes bothersome, it warrants further attention.
Other Potential Factors Contributing to Fatigue
Beyond direct hormonal influences, other common side effects of Nexplanon can indirectly contribute to fatigue. Irregular bleeding patterns, such as prolonged or heavy periods, are a frequently reported side effect. Significant or persistent blood loss can sometimes lead to iron deficiency anemia, a condition where the body lacks enough healthy red blood cells to carry oxygen, causing tiredness and weakness.
Hormonal contraception can also influence mood in some individuals, leading to emotional changes like lethargy or lack of motivation. Sadness, irritability, or mood swings, though distinct from physical tiredness, can contribute to reduced energy and weariness. Headaches are another possible side effect, and frequent or severe ones can be draining, depleting energy and causing tiredness. Changes in sleep quality can also directly impact daily energy levels.
Managing Tiredness and Consulting Your Doctor
For individuals experiencing tiredness while using Nexplanon, several self-care strategies can help. Ensure adequate sleep with a consistent schedule and comfortable environment. Adopt a balanced, nutrient-rich diet and stay well-hydrated. Regular physical activity, even moderate exercise, combats fatigue and boosts mood.
Monitor symptoms with a detailed journal to track severity, timing, and potential triggers. This record helps when discussing concerns with a healthcare provider. Consult a doctor if tiredness is severe, persistent, or significantly interferes with daily activities. Medical attention is also warranted if fatigue is accompanied by other concerning symptoms like dizziness, shortness of breath, significant mood changes, or unusually heavy or prolonged bleeding.
A healthcare provider can assess if fatigue relates to Nexplanon or other underlying conditions like anemia, thyroid issues, or vitamin deficiencies. They can provide an accurate diagnosis and recommend steps, including lifestyle adjustments, further investigation, or discussing alternative birth control if Nexplanon’s side effects are unmanageable. Only a medical professional can provide personalized advice based on health history and specific symptoms.
Citations
“Iron deficiency anemia – Symptoms & causes – Mayo Clinic.” Mayo Clinic, 11 Feb. 2023, www.mayoclinic.org/diseases-conditions/iron-deficiency-anemia/symptoms-causes/syc-20355027. Accessed 12 Sept. 2025.