RAD 140, also known as Testolone, is a selective androgen receptor modulator (SARM) that has gained considerable attention. It is a research chemical, meaning it is not approved for human use by regulatory bodies like the U.S. Food and Drug Administration (FDA). Despite its unapproved status, it is often discussed for its purported effects on body composition and athletic performance.
How RAD 140 Interacts with the Body
RAD 140 functions by selectively binding to androgen receptors in the body, primarily in muscle and bone tissues. This targeted action is intended to stimulate anabolic activity, which promotes muscle growth and bone density. By focusing its effects on these specific tissues, RAD 140 theoretically aims to minimize unwanted androgenic effects commonly associated with traditional anabolic steroids.
The mechanism of action involves mimicking the effects of natural androgens, such as testosterone, within these targeted tissues. This leads to enhanced muscle protein synthesis and increased lean mass. Unlike anabolic steroids that can affect multiple tissues throughout the body, RAD 140 is designed to have a more localized impact, reducing interaction with organs like the prostate or liver.
Observed Changes in Body and Performance
Users often report noticeable physical changes and performance enhancements when using RAD 140. Many describe rapid increases in lean muscle mass, with some anecdotal accounts suggesting gains of 7 to 21 pounds over an 8-week cycle. These gains are often accompanied by a fuller or bigger appearance in muscles, particularly in areas like the arms, chest, and legs.
Alongside muscle growth, users commonly report improvements in strength, allowing for more intense training sessions and increased workout capacity. Some individuals experience enhanced energy levels and reduced fatigue during workouts, leading to shorter rest times between sets and faster recovery. There are also claims of significant body fat reduction, with some users reporting a loss of around 12 to 13 pounds during a cycle, which contributes to a more defined and vascular physique.
Potential Unwanted Physiological Effects
Despite the reported benefits, RAD 140 is associated with several potential unwanted physiological effects. One of the most frequently reported concerns is testosterone suppression, particularly with higher doses or prolonged use. This occurs because RAD 140’s binding to androgen receptors can signal the body to reduce its own natural testosterone production through a feedback mechanism. The level of suppression can be significant, potentially leading to symptoms of low testosterone if not managed appropriately.
Liver strain is another reported adverse effect, as RAD 140, being an orally active compound, passes through the liver. While some suggest that proper use might minimize liver enzyme increases, cases of drug-induced liver injury, including cholestatic hepatitis, have been documented in individuals using RAD 140. Other potential effects include hair loss, especially in individuals with a predisposition to male pattern baldness, and potential mood changes.
Regulatory Landscape and Safety Warnings
RAD 140 is not approved for human consumption by regulatory authorities such as the FDA. It is often sold as a “research chemical,” which means it is intended for laboratory use only and not for ingestion. The FDA has issued warnings regarding SARMs, including RAD 140, citing potential life-threatening reactions like liver toxicity and an increased risk of heart attack and stroke.
The unregulated nature of these substances means there is a lack of oversight regarding their purity, dosage, and overall safety. Products sold online may contain incorrect dosages, undisclosed ingredients, or impurities. Furthermore, RAD 140 is explicitly prohibited in sports by anti-doping organizations like the World Anti-Doping Agency (WADA) due to its anabolic and performance-enhancing properties. Its use can lead to disqualification for competitive athletes.